The size of the gene symbol is relative to the count of samples with mutation in that gene. Can you please point to the URL. The Web site includes the database (requires registration), laboratory methods, forum and resources. Does COSMIC have the information about somatic mutation ? I only found information at the gene level (cancer consensus genes). Data are compiled from the peer-reviewed literature and from generalist databases.
separate dataset or view of our data: So I'm bit confused whether there is an existing database which consists of sequences having mutations in it. All the mutations in the TCGA database for that gene in that tumor are initially graphed, and if the number of mutations is >25, we remove the excess and plot the remainder ("Top 25").
They can be a primary source of cancer data, offer a certain level of analysis (processed data) or even offer online data mining. Mutation Databases The University of Utah Department of Pathology and ARUP Laboratories hosts a growing number of human gene variant-disease database collections. SMART and Pfam domain boundary mappings on to the amino acid sequence are also provided. We performed an extensive and thorough analysis of the TP53 mutation database, focusing particularly on specific sets of mutations that were overlooked in the past because of their low frequencies, for example, synonymous mutations, splice mutations, or mutations-targeting residues subject to posttranslational modifications. below. Leroy B(1), Anderson M, Soussi T. Author information: (1)Université Pierre et Marie Curie-Paris 6, Paris, 75005, France. This joint effort between the National Cancer Institute and the National Human Genome Research Institute began in 2006, bringing together researchers from diverse disciplines and multiple institutions. This is an international collaboration hosted by the NIH National Human Genome Research Institute. In total, GEMiCCL includes 1406 cell lines from 185 cancer types and 29 tissues.

somatic mutations in human cancer. COSMIC is divided into several distinct projects, each presenting a largest and most comprehensive resource for exploring the impact of This plot shows the most recurrently mutated cancer driver genes . Thank you ! An Open Access On-Line Breast Cancer Mutation Data Base An International Collaborative Effort hosted by NHGRI The recent identification of mutations in breast cancer susceptibility genes has provided the exciting opportunity to help identify women who are at high risk to develop breast cancer. See detailed information on database contents in the user's guide. Example Queries. Gene expression, mutation, and CNV information are available for 1304, 1334, and 1365 cell lines, respectively. Is there any database to get the mutated & non-mutated gene sequence?Here are some related resources that are focused on somatic mutations in cancer:BioStars post: BioStars post: Here is another generally relevant post: I'd suggest starting with Thank you SEAN but, it doesn't contain information for many other genes like BRCA1 & BRCA2The databases I noted above are about somatic mutation, not germline mutation.